Differential Mechanical Stability of Filamin A Rod Segments
نویسندگان
چکیده
منابع مشابه
Molecular structure of the rod domain of dictyostelium filamin.
Dictyostelium discoideum filamin (ddFLN) is a two-chain F-actin crosslinking protein with an N-terminal actin-binding domain and a rod domain constructed from six tandem repeats of a 100 residue motif that has an immunoglobulin (Ig) fold. We report the 2.8 A resolution crystal structure of a homodimer of rod repeats 4, 5 and 6. The two chains are arranged in an antiparallel fashion and form an ...
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Bovine rod outer segment (ROS) preparations contain a major 58 kDa protein doublet that was identified by immunoblot as tubulin. Quantification by gel densitometry showed that the total amount of tubulin was 5- to 10-fold higher than that attributable to the rod axoneme, suggesting additional role(s) for tubulin in photoreceptor cells. Approximately 20% of this nonaxonemal tubulin (15% of total...
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When Faraday identified/named diamagnetism (relative permeability μ < 1) in 1845, he reported in Arts. 2253-2260 of [1] that a glass rod would align itself at right angles to the lines of magnetic field of his laboratory electromagnet. He also noted in Art. 2269 that such object moved “into the positions of weakest magnetic action.” Faraday’s test objects were suspended from a string, but W. Th...
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A set of proteins in bovine rod outer segments is specifically methylated by S-adenosyl-L-methionine. The reaction can be demonstrated in the intact retina as well as in fragmented preparations of isolated rod outer segments. The apparent molecular weights of these proteins are 88,000, 61,000, and a subset between 21,000 and 26,000. The Mr = 88,000 protein is shown to be the alpha subunit of th...
متن کاملStudies on fragments of rod outer segments from bovine retinas.
Monolayers of fragments of our rod segments were formed at an air-water interface. The area of these particles was measured as a function of the pH of the aqueous phase. A maximum area was measured at pH 6.5. The film was characterised by measuring the decrease in surface pressure, after compression, and the half time required to reach constant pressure. At a pH between 6 and 7 the decrease in ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.07.028